PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of these metabolic programs is critical to successfully exploit them for therapy. Here, we report that the onco...

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Hauptverfasser: Vazquez, Francisca, Lim, Ji-Hong, Chim, Helen, Bhalla, Kavita, Girnun, Geoff, Pierce, Kerry, Clish, Clary B., Granter, Scott R., Widlund, Hans R., Spiegelman, Bruce M., Puigserver, Pere
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708305/
https://ncbi.nlm.nih.gov/pubmed/23416000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.020
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