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ERRα maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-elevated Melanomas

The uncontrolled growth of tumors provides metabolic dependencies that can be harnessed for therapeutic benefit. Although tumor cells exhibit these increased metabolic demands due to their rapid proliferation, these metabolic processes are general to all cells, and furthermore, targeted therapeutic...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Res
Päätekijät: Luo, Chi, Balsa, Eduardo, Thomas, Ajith, Hatting, Maximilian, Jedrychowski, Mark, Gygi, Steven P., Widlund, Hans R., Puigserver, Pere
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954239/
https://ncbi.nlm.nih.gov/pubmed/28596418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0143
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