N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor γ Ligand with Partial and Full Agonist Activity in Vitro and in Vivo

The thiazolidedione (TZD) class of drugs is clinically approved for the treatment of type 2 diabetes. The therapeutic actions of TZDs are mediated via activation of peroxisome proliferator-activated receptor γ (PPARγ). Despite their widespread use, concern exists regarding the safety of currently us...

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Hlavní autoři: Bhalla, Kavita, Hwang, Bor Jang, Choi, Jang Hyun, Dewi, Ruby, Ou, Lihui, Mclenithan, John, Twaddel, William, Pozharski, Edwin, Stock, Jeffry, Girnun, Geoffrey D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308872/
https://ncbi.nlm.nih.gov/pubmed/21979952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257915
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