To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations

Chiglitazar is a promising new-generation insulin sensitizer with low reverse effects for the treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan-agonist to the human peroxisome proliferator-activated receptors (PPARs) (i.e., full activation of PPARγ and a part...

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Vydáno v:PPAR Res
Hlavní autoři: Sullivan, Holli-Joi, Wang, Xiaoyan, Nogle, Shaina, Liao, Siyan, Wu, Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152983/
https://ncbi.nlm.nih.gov/pubmed/32308671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5314187
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