Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of...

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Detalhes bibliográficos
Main Authors: Liberato, Marcelo Vizoná, Nascimento, Alessandro S., Ayers, Steven D., Lin, Jean Z., Cvoro, Aleksandra, Silveira, Rodrigo L., Martínez, Leandro, Souza, Paulo C. T., Saidemberg, Daniel, Deng, Tuo, Amato, Angela Angelica, Togashi, Marie, Hsueh, Willa A., Phillips, Kevin, Palma, Mário Sérgio, Neves, Francisco A. R., Skaf, Munir S., Webb, Paul, Polikarpov, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359336/
https://ncbi.nlm.nih.gov/pubmed/22649490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036297
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