Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of...

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Manylion Llyfryddiaeth
Prif Awduron: Liberato, Marcelo Vizoná, Nascimento, Alessandro S., Ayers, Steven D., Lin, Jean Z., Cvoro, Aleksandra, Silveira, Rodrigo L., Martínez, Leandro, Souza, Paulo C. T., Saidemberg, Daniel, Deng, Tuo, Amato, Angela Angelica, Togashi, Marie, Hsueh, Willa A., Phillips, Kevin, Palma, Mário Sérgio, Neves, Francisco A. R., Skaf, Munir S., Webb, Paul, Polikarpov, Igor
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359336/
https://ncbi.nlm.nih.gov/pubmed/22649490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036297
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