PEPCK coordinates the regulation of central carbon metabolism to promote cancer cell growth

Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis. However, PEPCK is also a key regulator of TCA cycle flux. The TCA cycle integrates glucose, amino acid and lipid metabolism depending on cellular needs. In addition, biosynthetic pathways crucial to tumor growth...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Montal, Emily, Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley, Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Lazlo, Shroyer, Kenneth, Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656111/
https://ncbi.nlm.nih.gov/pubmed/26481663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.025
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