The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional regulatory properties. Although therapeutic targeting of most leukemia fusion proteins remains elusive, the posttranslational modifications that cont...

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Bibliographic Details
Main Authors: Wang, Lan, Gural, Alexander, Sun, Xiao-Jian, Zhao, Xinyang, Perna, Fabiana, Huang, Gang, Hatlen, Megan A., Vu, Ly, Liu, Fan, Xu, Haiming, Asai, Takashi, Xu, Hao, Deblasio, Tony, Menendez, Silvia, Voza, Francesca, Jiang, Yanwen, Cole, Philip A., Zhang, Jinsong, Melnick, Ari, Roeder, Robert G., Nimer, Stephen D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251012/
https://ncbi.nlm.nih.gov/pubmed/21764752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1201662
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