Llwytho...

New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins

BACKGROUND: Nearly 15% of acute myeloid leukemia (AML) cases are caused by aberrant expression of AML1-ETO, a fusion protein generated by the t(8;21) chromosomal translocation. Since its discovery, AML1-ETO has served as a prototype to understand how leukemia fusion proteins deregulate transcription...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Biol (Beijing)
Prif Awduron: Li, Jian, Guo, Chun, Steinauer, Nickolas, Zhang, Jinsong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336278/
https://ncbi.nlm.nih.gov/pubmed/28261265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-016-1415-1
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