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New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins
BACKGROUND: Nearly 15% of acute myeloid leukemia (AML) cases are caused by aberrant expression of AML1-ETO, a fusion protein generated by the t(8;21) chromosomal translocation. Since its discovery, AML1-ETO has served as a prototype to understand how leukemia fusion proteins deregulate transcription...
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| Udgivet i: | Front Biol (Beijing) |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5336278/ https://ncbi.nlm.nih.gov/pubmed/28261265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-016-1415-1 |
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