Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1–ETO–dependent transcription in t(8;21) AML

In up to 15% of acute myeloid leukemias (AMLs), a recurring chromosomal translocation, termed t(8;21), generates the AML1–eight–twenty-one (ETO) leukemia fusion protein, which contains the DNA-binding domain of Runt-related transcription factor 1 (RUNX1) and almost all of ETO. RUNX1 and the AML1–ETO...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Guo, Chun, Li, Jian, Steinauer, Nickolas, Wong, Madeline, Wu, Brent, Dickson, Alexandria, Kalkum, Markus, Zhang, Jinsong
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105303/
https://ncbi.nlm.nih.gov/pubmed/32071087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010707
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