A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis

Transcription factors are frequently altered in leukaemia through chromosomal translocation, mutation or aberrant expression(1). AML1-ETO, a fusion protein generated by the t(8;21) translocation in acute myeloid leukaemia (AML), is a transcription factor implicated in both gene repression and activa...

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Hauptverfasser: Sun, Xiao-Jian, Wang, Zhanxin, Wang, Lan, Jiang, Yanwen, Kost, Nils, Soong, T. David, Chen, Wei-Yi, Tang, Zhanyun, Nakadai, Tomoyoshi, Elemento, Olivier, Fischle, Wolfgang, Melnick, Ari, Patel, Dinshaw J., Nimer, Stephen D., Roeder, Robert G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732535/
https://ncbi.nlm.nih.gov/pubmed/23812588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12287
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