FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

Calmodulin (CaM) binding to the type 2 ryanodine receptor (RyR2) regulates Ca release from the cardiac sarcoplasmic reticulum (SR). However, the structural basis of CaM regulation of the RyR2 is poorly defined, and the presence of other potential CaM binding partners in cardiac myocytes complicates...

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Autors principals: Guo, Tao, Fruen, Bradley R., Nitu, Florentin R., Nguyen, Trinh D., Yang, Yi, Cornea, Razvan L., Bers, Donald M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
Matèries:
Channels and Transporters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207159/
https://ncbi.nlm.nih.gov/pubmed/22067155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.09.030
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