HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma

Mantle cell lymphoma (MCL) usually responds well to initial therapy but is prone to relapses with chemoresistant disease, indicating the need for novel therapeutic approaches. Inhibition of the p53 E3 ligase human homolog of the murine double minute protein-2 (HDM-2) with MI-63 has been validated as...

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Bibliographic Details
Main Authors: Jones, Richard J., Baladandayuthapani, Veerabhadran, Neelapu, Sattva, Fayad, Luis E., Romaguera, Jorge E., Wang, Michael, Sharma, Rakesh, Yang, Dajun, Orlowski, Robert Z.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204731/
https://ncbi.nlm.nih.gov/pubmed/21844567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-340323
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