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8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma
8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls the activity of mammalian target of rapamycin (mTOR), we hypothesized that 8-NH...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031409/ https://ncbi.nlm.nih.gov/pubmed/20844237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285866 |
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