8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls the activity of mammalian target of rapamycin (mTOR), we hypothesized that 8-NH...

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Detaylı Bibliyografya
Asıl Yazarlar: Dennison, Jennifer B., Shanmugam, Mala, Ayres, Mary L., Qian, Jun, Krett, Nancy L., Medeiros, L. Jeffrey, Neelapu, Sattva S., Rosen, Steven T., Gandhi, Varsha
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2010
Konular:
Lymphoid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031409/
https://ncbi.nlm.nih.gov/pubmed/20844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285866
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