8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls the activity of mammalian target of rapamycin (mTOR), we hypothesized that 8-NH...

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Détails bibliographiques
Auteurs principaux: Dennison, Jennifer B., Shanmugam, Mala, Ayres, Mary L., Qian, Jun, Krett, Nancy L., Medeiros, L. Jeffrey, Neelapu, Sattva S., Rosen, Steven T., Gandhi, Varsha
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031409/
https://ncbi.nlm.nih.gov/pubmed/20844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285866
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