Chargement en cours...

8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls the activity of mammalian target of rapamycin (mTOR), we hypothesized that 8-NH...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Dennison, Jennifer B., Shanmugam, Mala, Ayres, Mary L., Qian, Jun, Krett, Nancy L., Medeiros, L. Jeffrey, Neelapu, Sattva S., Rosen, Steven T., Gandhi, Varsha
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031409/
https://ncbi.nlm.nih.gov/pubmed/20844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285866
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!