Targeting Glucose Consumption and Autophagy in Myeloma with the Novel Nucleoside Analogue 8-Aminoadenosine

Multiple myeloma, an incurable plasma cell malignancy, is characterized by altered cellular metabolism and resistance to apoptosis. Recent connections between glucose metabolism and resistance to apoptosis provide a compelling rationale for targeting metabolic changes in cancer. In this study, we ha...

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Detalhes bibliográficos
Main Authors: Shanmugam, Mala, McBrayer, Samuel K., Qian, Jun, Raikoff, Kiril, Avram, Michael J., Singhal, Seema, Gandhi, Varsha, Schumacker, Paul T., Krett, Nancy L., Rosen, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785370/
https://ncbi.nlm.nih.gov/pubmed/19648108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000646
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