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8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls the activity of mammalian target of rapamycin (mTOR), we hypothesized that 8-NH...

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Detalhes bibliográficos
Main Authors: Dennison, Jennifer B., Shanmugam, Mala, Ayres, Mary L., Qian, Jun, Krett, Nancy L., Medeiros, L. Jeffrey, Neelapu, Sattva S., Rosen, Steven T., Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031409/
https://ncbi.nlm.nih.gov/pubmed/20844237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-285866
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