Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas

Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in the context of HIV infection. Kaposi sarcoma–associated herpesvirus is the causative agent of PEL. The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in c...

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Bibliographic Details
Main Authors: Bhatt, Aadra P., Bhende, Prasanna M., Sin, Sang-Hoon, Roy, Debasmita, Dittmer, Dirk P., Damania, Blossom
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881502/
https://ncbi.nlm.nih.gov/pubmed/20299510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251082
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