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Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5′-diphosphate
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside 5′–diphosphates to the corresponding deoxynucleotides supplying the dNTPs required for DNA replication and DNA repair. Class I RNRs require two subunits, α and β, for activity. Humans possess two β subunits: one involved in S pha...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917093/ https://ncbi.nlm.nih.gov/pubmed/19899807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901588z |
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