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Inactivation of Lactobacillus leichmannii ribonucleotide reductase by F(2)CTP: adenosylcobalamin destruction and formation of a nucleotide based radical
Ribonucleotide reductase (RNR, 76 kDa) from Lactobacillus leichmannii is a class II RNR that requires adenosylcobalamin (AdoCbl) as a cofactor. It catalyzes the conversion on nucleoside triphosphates to deoxynucleotides and is 100% inactivated by one equivalent (eq.) of 2′,2′-difluoro-2′-deoxycytidi...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867335/ https://ncbi.nlm.nih.gov/pubmed/20088568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9021318 |
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