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Conformationally-Dynamic Radical Transfer within Ribonucleotide Reductase

Ribonucleotide reductases (RNR) catalyze the reduction of nucleotides to deoxynucleotides through a mechanism involving an essential cysteine based thiyl radical. In the E. coli class 1a RNR the thiyl radical (C(439)•) is a transient species generated by radical transfer (RT) from a stable diferric-...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Greene, Brandon L., Taguchi, Alexander T., Stubbe, JoAnne, Nocera, Daniel G.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702266/
https://ncbi.nlm.nih.gov/pubmed/29037038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08192
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