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Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable of generating 2′-deoxynucleotides de novo and are thus critical in DNA biosynthesis and repair. The nucleotide reduction reaction in all RNRs requires the generation of a transient active site thiyl radical, and...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Kang, Gyunghoon, Taguchi, Alexander T., Stubbe, JoAnne, Drennan, Catherine L.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774503/
https://ncbi.nlm.nih.gov/pubmed/32217749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba6794
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