Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer

Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside diphosphate substrates (S) to deoxynucleotides with allosteric effectors (e) controlling their relative ratios and amounts, crucial for fidelity of DNA replication and repair. Escherichia coli class Ia RNR is composed of α and β...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Lin, Qinghui, Parker, Mackenzie J., Taguchi, Alexander T., Ravichandran, Kanchana, Kim, Albert, Kang, Gyunghoon, Shao, Jimin, Drennan, Catherine L., Stubbe, JoAnne
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454104/
https://ncbi.nlm.nih.gov/pubmed/28377505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783092
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