Glutamate 350 plays an essential role in conformational gating of long range radical transport in E. coli class Ia ribonucleotide reductase

E. coli Ia ribonucleotide reductase is composed of two subunits that form an active α2β2 complex. The nucleoside diphosphate substrates (NDP) are reduced in α2, 35 Å from the essential diferric-tyrosyl radical (Y(122)•) cofactor in β2. The Y(122)• mediated oxidation of C(439) in α2 occurs by a pathw...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry
Main Authors: Ravichandran, Kanchana, Minnihan, Ellen C., Lin, Qinghui, Yokoyama, Kenichi, Taguchi, Alexander T., Shao, Jimin, Nocera, Daniel J., Stubbe, JoAnne
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689411/
https://ncbi.nlm.nih.gov/pubmed/28103007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01145
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items