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Gated Proton Release During Radical Transfer at the Subunit Interface of Ribonucleotide Reductase

The class Ia ribonucleotide reductase of Escherichia coli requires strict regulation of long-range radical transfer between two subunits, α and β, through a series of redox-active amino acids (Y(122)•[β] ↔ W(48)?[β] ↔ Y(356)[β] ↔ Y(731)[α] ↔ Y(730)[α] ↔ C(439)[α]). Nowhere is this more precarious th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Cui, Chang, Greene, Brandon L., Kang, Gyunghoon, Drennan, Catherine L., Stubbe, JoAnne, Nocera, Daniel G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904477/
https://ncbi.nlm.nih.gov/pubmed/33353307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c07879
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