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Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex
Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable of generating 2′-deoxynucleotides de novo and are thus critical in DNA biosynthesis and repair. The nucleotide reduction reaction in all RNRs requires the generation of a transient active site thiyl radical, and...
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| 發表在: | Science |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7774503/ https://ncbi.nlm.nih.gov/pubmed/32217749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba6794 |
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