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Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5′-diphosphate in the presence or absence of reductant
Gemcitabine 5′-diphosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication and repair. The E. coli RNR, an α2β2 complex, when incubated with one equivalent of F(2)CDP catalyzes the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917094/ https://ncbi.nlm.nih.gov/pubmed/19899770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901590q |
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