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Enhanced subunit interactions with gemcitabine-5′-diphosphate inhibit ribonucleotide reductases
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. The class I RNRs are composed of two subunits, α and β, with proposed quaternary structures of α2β2, α6β2, or α6β6, depending on the organism. The α subunits bind the nucleoside diphosphate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1964847/ https://ncbi.nlm.nih.gov/pubmed/17726094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706803104 |
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