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Enhanced subunit interactions with gemcitabine-5′-diphosphate inhibit ribonucleotide reductases

Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. The class I RNRs are composed of two subunits, α and β, with proposed quaternary structures of α2β2, α6β2, or α6β6, depending on the organism. The α subunits bind the nucleoside diphosphate...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Wang, Jun, Lohman, Gregory J. S., Stubbe, JoAnne
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964847/
https://ncbi.nlm.nih.gov/pubmed/17726094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706803104
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