HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma

Mantle cell lymphoma (MCL) usually responds well to initial therapy but is prone to relapses with chemoresistant disease, indicating the need for novel therapeutic approaches. Inhibition of the p53 E3 ligase human homolog of the murine double minute protein-2 (HDM-2) with MI-63 has been validated as...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Jones, Richard J., Baladandayuthapani, Veerabhadran, Neelapu, Sattva, Fayad, Luis E., Romaguera, Jorge E., Wang, Michael, Sharma, Rakesh, Yang, Dajun, Orlowski, Robert Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204731/
https://ncbi.nlm.nih.gov/pubmed/21844567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-340323
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk