HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma

Mantle cell lymphoma (MCL) usually responds well to initial therapy but is prone to relapses with chemoresistant disease, indicating the need for novel therapeutic approaches. Inhibition of the p53 E3 ligase human homolog of the murine double minute protein-2 (HDM-2) with MI-63 has been validated as...

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Detalhes bibliográficos
Principais autores: Jones, Richard J., Baladandayuthapani, Veerabhadran, Neelapu, Sattva, Fayad, Luis E., Romaguera, Jorge E., Wang, Michael, Sharma, Rakesh, Yang, Dajun, Orlowski, Robert Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204731/
https://ncbi.nlm.nih.gov/pubmed/21844567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-340323
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