Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions

The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA lesions is poorly understood. To address this issue, we have studied NER in human HeLa cell extracts of two topologically distinct lesions, one derived from benzo[a]pyrene (10R-(+)-cis-anti-B[a]P-N(2)-dG), and...

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Detalhes bibliográficos
Main Authors: Reeves, Dara A., Mu, Hong, Kropachev, Konstantin, Cai, Yuqin, Ding, Shuang, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, Chen, Ying, Krzeminski, Jacek, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203604/
https://ncbi.nlm.nih.gov/pubmed/21764772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr537
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