Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a singl...

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Detalhes bibliográficos
Main Authors: Mu, Hong, Kropachev, Konstantin, Wang, Lihua, Zhang, Lu, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, E. Geacintov, Nicholas, Broyde, Suse
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479214/
https://ncbi.nlm.nih.gov/pubmed/22904073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks788
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