Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a singl...

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Hlavní autoři: Mu, Hong, Kropachev, Konstantin, Wang, Lihua, Zhang, Lu, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, E. Geacintov, Nicholas, Broyde, Suse
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479214/
https://ncbi.nlm.nih.gov/pubmed/22904073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks788
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