Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions

The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA lesions is poorly understood. To address this issue, we have studied NER in human HeLa cell extracts of two topologically distinct lesions, one derived from benzo[a]pyrene (10R-(+)-cis-anti-B[a]P-N(2)-dG), and...

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Main Authors: Reeves, Dara A., Mu, Hong, Kropachev, Konstantin, Cai, Yuqin, Ding, Shuang, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, Chen, Ying, Krzeminski, Jacek, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203604/
https://ncbi.nlm.nih.gov/pubmed/21764772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr537
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