Determinants of successful CD8(+) T cell adoptive immunotherapy for large established tumors in mice

PURPOSE: Adoptive cell transfer (ACT) of tumor-infiltrating or genetically engineered T cells can cause durable responses in patients with metastatic cancer. Multiple clinically-modifiable parameters can comprise this therapy, including cell dose and phenotype, in vivo antigen re-stimulation, and co...

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Detalhes bibliográficos
Main Authors: Klebanoff, Christopher A., Gattinoni, Luca, Palmer, Douglas C., Muranski, Pawel, Ji, Yun, Hinrichs, Christian S., Borman, Zachary A., Kerkar, Sid P., Scott, Christopher D., Finkelstein, Steven E., Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176721/
https://ncbi.nlm.nih.gov/pubmed/21737507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0503
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