Human effector CD8(+) T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

Cluster of differentiation (CD)8(+) T cells exist as naive, central memory, and effector memory subsets, and any of these populations can be genetically engineered into tumor-reactive effector cells for adoptive immunotherapy. However, the optimal subset from which to derive effector CD8(+) T cells...

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Main Authors: Hinrichs, Christian S., Borman, Zachary A., Gattinoni, Luca, Yu, Zhiya, Burns, William R., Huang, Jianping, Klebanoff, Christopher A., Johnson, Laura A., Kerkar, Sid P., Yang, Shicheng, Muranski, Pawel, Palmer, Douglas C., Scott, Christopher D., Morgan, Richard A., Robbins, Paul F., Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035075/
https://ncbi.nlm.nih.gov/pubmed/20971955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-286286
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