Adoptively transferred effector cells derived from naïve rather than central memory CD8(+) T cells mediate superior antitumor immunity

Effector cells derived from central memory CD8(+) T cells were reported to engraft and survive better than those derived from effector memory populations, suggesting that they are superior for use in adoptive immunotherapy studies. However, previous studies did not evaluate the relative efficacy of...

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Main Authors: Hinrichs, Christian S., Borman, Zachary A., Cassard, Lydie, Gattinoni, Luca, Spolski, Rosanne, Yu, Zhiya, Sanchez-Perez, Luis, Muranski, Pawel, Kern, Steven J., Logun, Carol, Palmer, Douglas C., Ji, Yun, Reger, Robert N., Leonard, Warren J., Danner, Robert L., Rosenberg, Steven A., Restifo, Nicholas P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762661/
https://ncbi.nlm.nih.gov/pubmed/19805141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907448106
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