Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8(+) T cells via TLR4 signaling

Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8(+) T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine levels. We found that TBI augmented the function of adoptively transferred CD8(+) T cells in mice g...

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Bibliografische gegevens
Hoofdauteurs: Paulos, Chrystal M., Wrzesinski, Claudia, Kaiser,, Andrew, Hinrichs, Christian S., Chieppa, Marcello, Cassard, Lydie, Palmer, Douglas C., Boni, Andrea, Muranski, Pawel, Yu, Zhiya, Gattinoni, Luca, Antony, Paul A., Rosenberg, Steven A., Restifo, Nicholas P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2007
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924500/
https://ncbi.nlm.nih.gov/pubmed/17657310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32205
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