Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8(+) T cells

Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8(+) T cells significantly enhances tumor treatment. In the current study, superior antitumor efficacy was achieved by further increasing the intensity of lymphodepletion to a level that...

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Hauptverfasser: Wrzesinski, Claudia, Paulos, Chrystal M., Gattinoni, Luca, Palmer, Douglas C., Kaiser, Andrew, Yu, Zhiya, Rosenberg, Steven A., Restifo, Nicholas P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783812/
https://ncbi.nlm.nih.gov/pubmed/17273561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30414
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