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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8(+) T cells
T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8(+) T cells into tumor-bearing mice at various stages of differentiation, we evaluated their efficacy for adoptive immunotherapy. We found that administration of naiv...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1137001/ https://ncbi.nlm.nih.gov/pubmed/15931392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24480 |
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