IL-2 and IL-21 confer opposing differentiation programs to CD8(+) T cells for adoptive immunotherapy

IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8(+) T cells, but their distinct effects on antigen-driven differentiation of naive CD8(+) T cells into effector CD8(+) T cells are not clearly understood. We fo...

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Main Authors: Hinrichs, Christian S., Spolski, Rosanne, Paulos, Chrystal M., Gattinoni, Luca, Kerstann, Keith W., Palmer, Douglas C., Klebanoff, Christopher A., Rosenberg, Steven A., Leonard, Warren J., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396726/
https://ncbi.nlm.nih.gov/pubmed/18276844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113050
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