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Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

Interleukin 9 (IL-9) is a γ(c)-family cytokine that is highly produced by T-helper 9 (Th9) cells and regulates a range of immune responses, including allergic inflammation. Here we show that IL-2–JAK3–STAT5 signaling is required for Th9 differentiation, with critical STAT5 binding sites in the Il9 (...

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Detalhes bibliográficos
Main Authors: Liao, Wei, Spolski, Rosanne, Li, Peng, Du, Ning, West, Erin E., Ren, Min, Mitra, Suman, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948278/
https://ncbi.nlm.nih.gov/pubmed/24550509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301138111
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