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IL-21 mediates suppressive effects via its induction of IL-10
IL-21 is a pleiotropic cytokine that is required for normal immunoglobulin production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus erythematosus. These mice also have elevated IL-10 levels, and we now show that IL-21 induces IL-10 mRNA and protein, suggesting un...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756221/ https://ncbi.nlm.nih.gov/pubmed/19234181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802978 |
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