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IL-21 Promotes the Pathologic Immune Response to Pneumovirus Infection

IL-21 is a cytokine with pleiotropic actions, promoting terminal differentiation of B cells, increased immunoglobulin production, and the development of Th17 and T follicular helper cells. IL-21 is also implicated in the development of autoimmune disease and has anti-tumor activity. Here we investig...

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Detalhes bibliográficos
Main Authors: Spolski, Rosanne, Wang, Lu, Wan, Chi-Keung, Bonville, Cynthia A., Domachowske, Joseph B., Kim, Hyoung-Pyo, Yu, Zuxi, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277853/
https://ncbi.nlm.nih.gov/pubmed/22238461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100767
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