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IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor γ chain and plays important roles for normal Ig production, terminal B cell differentiation to plasma cells, and Th17 differentiation. IL-21 is elevated in several autoimmune diseases, and blocking its action has attenua...

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Bibliografski detalji
Glavni autori: Spolski, Rosanne, Kashyap, Mohit, Robinson, Constance, Yu, Zuxi, Leonard, Warren J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544573/
https://ncbi.nlm.nih.gov/pubmed/18779574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804358105
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