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IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor γ chain and plays important roles for normal Ig production, terminal B cell differentiation to plasma cells, and Th17 differentiation. IL-21 is elevated in several autoimmune diseases, and blocking its action has attenua...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544573/ https://ncbi.nlm.nih.gov/pubmed/18779574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804358105 |
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