A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that affects the differentiation and function of T, B, and NK cells by binding to a receptor consisting of the common cytokine receptor γ chain and the IL-21 receptor (IL-21R). IL-21, a product associated with IL-17-producing C...

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Библиографические подробности
Главные авторы: Bubier, Jason A., Sproule, Thomas J., Foreman, Oded, Spolski, Rosanne, Shaffer, Daniel J., Morse, Herbert C., Leonard, Warren J., Roopenian, Derry C.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2009
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635818/
https://ncbi.nlm.nih.gov/pubmed/19164519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807309106
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