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4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing
The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library is reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy was assayed using epithelial cells expressing human ΔF508-CFTR. T...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166558/ https://ncbi.nlm.nih.gov/pubmed/18394886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.037 |
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