Lack of Maternal Glutamate Cysteine Ligase Modifier Subunit (Gclm) Decreases Oocyte Glutathione Concentrations and Disrupts Preimplantation Development in Mice

Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have decreased GSH synthesis. Nicotinamide nucleotide transhydrogenase,...

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Autores principales: Nakamura, Brooke N., Fielder, Thomas J., Hoang, Yvonne D., Lim, Jinhwan, McConnachie, Lisa A., Kavanagh, Terrance J., Luderer, Ulrike
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2011
Materias:
Reproduction-Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115613/
https://ncbi.nlm.nih.gov/pubmed/21558310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0207
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