Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

Glutamate cysteine ligase (GCL) catalyzes the rate-limiting step in the formation of the cellular antioxidant glutathione (GSH). The GCL holoenzyme consists of two separately coded proteins, a catalytic subunit (GCLC) and a modifier subunit (GCLM). Both GCLC and GLCM are controlled transcriptionally...

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Detalhes bibliográficos
Main Authors: Krejsa, Cecile M., Franklin, Christopher C., White, Collin C., Ledbetter, Jeffrey A., Schieven, Gary L., Kavanagh, Terrance J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871480/
https://ncbi.nlm.nih.gov/pubmed/20332089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116210
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