Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and rate-limiting step in GSH synthesis is catalyzed by glutamate cysteine ligase (GCL, previously known as γ-glutamylcysteine synthetase). GCL is a heterodimeric protein composed of catalytic (GCLC) and modifi...

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Detalhes bibliográficos
Main Authors: Franklin, Christopher C., Backos, Donald S., Mohar, Isaac, White, Collin C., Forman, Henry J., Kavanagh, Terrance J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714364/
https://ncbi.nlm.nih.gov/pubmed/18812186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mam.2008.08.009
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