Lack of Maternal Glutamate Cysteine Ligase Modifier Subunit (Gclm) Decreases Oocyte Glutathione Concentrations and Disrupts Preimplantation Development in Mice

Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have decreased GSH synthesis. Nicotinamide nucleotide transhydrogenase,...

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Detalhes bibliográficos
Main Authors: Nakamura, Brooke N., Fielder, Thomas J., Hoang, Yvonne D., Lim, Jinhwan, McConnachie, Lisa A., Kavanagh, Terrance J., Luderer, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115613/
https://ncbi.nlm.nih.gov/pubmed/21558310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0207
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