Increased Sensitivity to Testicular Toxicity of Transplacental Benzo[a]pyrene Exposure in Male Glutamate Cysteine Ligase Modifier Subunit Knockout (Gclm−/−) Mice

Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BaP), are ubiquitous environmental pollutants formed by the incomplete combustion of organic materials. The tripeptide glutathione (GSH) is a major antioxidant and is important in detoxification of PAH metabolites. Mice null for the modif...

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Главные авторы: Nakamura, Brooke N., Mohar, Isaac, Lawson, Gregory W., Cortés, Mabel M., Hoang, Yvonne D., Ortiz, Laura, Patel, Reshma, Rau, Bogdan A., McConnachie, Lisa A., Kavanagh, Terrance J., Luderer, Ulrike
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Reproductive and Developmental Toxicology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289497/
https://ncbi.nlm.nih.gov/pubmed/22253057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs017
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