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Re-engineering the polymerase domain of Klenow fragment and evaluation of overproduction and purification strategies.

We describe experiments to produce large quantities of the polymerase domain of E. coli DNA polymerase I for biochemical and biophysical studies. The polymerase domain derivative used in previous studies was insoluble when overproduced and tended to aggregate during purification. These problems were...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Derbyshire, V, Astatke, M, Joyce, C M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1993
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC310583/
https://ncbi.nlm.nih.gov/pubmed/8265361
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